AI-Edigene? EGFR p.C797S Reference Standard Plus
CBP10341
詢(xún) 價(jià)
索取COA
產(chǎn)品描述
產(chǎn)品數據庫
| Introduction | |
| Format | Genomic DNA |
| Description | EGFR C797S lies within the ATP-binding pocket in the protein kinase domain of the Egfr protein (PMID: 25964297). C797S has been demonstrated to confer resistance to third-generation EGFR inhibitors (PMID: 25964297, PMID: 25948633, PMID: 29410323), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jun 2018). |
| Technical Data | |
| DNA Change: | c.2389T>A |
| AA Change | p.C797S |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000275493 |
| Chr position(GRCh37) | COSM6493937 |
| Chr position(GRCh37) | chr7:55249091 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1µg |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
